Hematopoiesis, the process by which mature blood cells of distinct lineages (e.g., red, white and lymphoid) are produced from pluripotent hematopoietic stem cells, is a highly orchestrated process. Aberrances in this intricate process may lead to malignancy of essential blood-forming organs, causing diseases such as leukemia. Gene expression is determined by the interaction of positive and negative regulators of gene transcription; therefore, transcription factors (TF) and their cis-regulatory elements play an integral role in hematopoietic control. The Hematopoiesis Promoter Database (HemoPDB) has been developed as a publicly available, web-based information resource focused on transcriptional regulation in hematopoiesis. HemoPDB is composed of integral, experimentally defined regulatory information, including TFs, cis-regulatory elements, their target gene promoters and corresponding annotations, with links to supporting published references. Accordingly, the database may be searched by Gene Symbol, GenBank Accession Number, UniGene ID, TF (binding site) Name and lineage or cell type within which a gene is expressed. (Please read the README file for a sample tutorial or download the PDF file). Currently, HemoPDB contains 246 promoter sequences and 604 experimentally known cis-regulatory elements of 187 different TFs. Organisms available, thus far, are human and mouse. We are continuously adding relevant data as they become available, to ensure inclusion of the most recent information.

A list of TFs in HemoPDB, where aberrances are known to be involved with specific diseases, and their combinatorially associating TFs, is available in the SUPPLEMENTARY TABLE. This table was composed by manually reviewing several articles. Please click on REVIEW ARTICLES for a list of relevant, recently published literature.

Documentation and more detailed information about the HemoPDB Database Schema are available HERE.

For further information or would like to include your published research findings in HemoPDB, please contact Twyla Tiongson Pohar or Ramana V. Davuluri