Anirban Bhattacharyya, Ph.D.
Postdoctoral Research Fellow
 215-495-6837  anirban@wistar.org
Anirban joined Davuluri Lab in November 2007, and moved to Wistar in April 2008. He received his PhD in theoretical Nuclear Physics from The Ohio State University in August 2005 under the supervision of Dr. R.J.Furnstahl. His PhD research was on combining two many-body-theory approachs into one systematic framework. He did his postdoctoral research in Oak Ridge National laboratory under the supervision of Dr. T. Papenbrock. He worked in industry for a year as a database administrator and data analyst before joining Davuluri lab. He is currently investigating how the usage of alternative promoters affect splicing.
Publications
Usage of Alternative First Exons affect Splicing, A. Bhattacharyya, S. Pal, R.V. Davuluri, in preparation.
In silico prediction of target SNPs affecting miR-mRNA interaction, H. Sun, M.S. Nicoloso, A. Bhattacharyya, G.A. Calin, R.V. Davuluri, 2008 IEEE international conference on Bioinformatics and Biomedicine Workshops.
Past Publications
Density Functional Theory for the Pairing Hamiltonian, T. Papenbrock, A. Bhattacharyya, Phys. Rev. C 75, 014304, 2007
Density Functional Theory for Fermions close to the Unitary Regime, A. Bhattacharyya, T. Papenbrock, Phys. Rev. A 74, 041602(R), 2006
Single-Particle Properties from Kohn-Sham Green's Functions, A. Bhattacharyya, R.J. Furnstahl, Physics Letters B 607: 259-266, 2005.
The Kinetic Energy Density in Kohn-Sham Density Functional Theory, A. Bhattacharyya, R.J. Furnstahl, Nucl. Phys. A 747: 268-294, 2005.
Density Functional Theory for a Confined Fermi System with Short-Range Interaction, S.J. Puglia, A. Bhattacharyya, R.J. Furnstahl, Nucl. Phys. A 723: 145-180, 2003.
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Sharmistha Pal, Ph.D.
Postdoctoral Research Fellow
215-898-3902 spal@wistar.org
Sharmistha joined Center for Systems & Computational Biology, Davuluri Lab in August 2008. She received her PhD in 2007 in Molecular, Cellular and Developmental Biology at the Ohio State University, Columbus, Ohio. She continued to work as a postdoctoral researcher at Ohio State University for a year before joining Dr. Davuluri's group at the Wistar Institute. Her Ph.D was focused on understanding the role of hSWI/SNF associated PRMT5 methyltransferase in transcrioptional regulation and cancer. Her current work focuses on identifying the usage of alternate promoters and understanding their role in regulating gene expression during development and in cancer using high throughput ChIP-seq technology.
Publications
Wang L., Pal S., Sif S. 2008. PRMT5 Suppresses the Transcription of the RB Family of Tumor Suppressors in Leukemia and Lymphoma Cells. Mol. Cell. Biol. 28: 6262-6277.
Pal S., Sif S.2007. Interplay between chromatin remodelers and protein arginine methyltransferases. J. Cell Physiol. 213:306-315. (Review)
Pal S., Baiocchi RA., Byrd JC., Grever MR., Jacob ST., Sif S. 2007. Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma. EMBO J. 26:3558-3569.
Dacwag CS., Ohkawa Y., Pal S., Sif S., Imbalzano AN. 2007. The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling. Mol Cell Biol. 27:384-394.
Harikrishnan KN, Pal S, Yarski M, Baker EK, Chow MZ, de Silva MG, Okabe J, Wang L, Jones PL,Sif S, and & El-Osta A. 2006. Reply to:Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex.. Nature Genetics 38: 964-967.
Wang L., Baiocchi RA., Pal S., Mosialos G., Caliguiri M., Sif S. 2005. The BRG1 and hBRM-associated factor BAF57 induces apoptosis by stimulating expression of the cylindromatosis tumor suppressor gene. Mol. Cell. Biol. 25:7953-7965.
Harikrishnan KN1., Chow MZ1., Baker EK1., Pal S1., Bassal S., Brasacchio D., Wang L., Craig JM., Jones PL., Sif S., El-Osta A. 2005. Brahma links the SWI/SNF chromatin remodeling complex with MeCP2-dependent transcriptional silencing. Nature Genetics 37: 254-264. (1 These authors contributed equally to this work and this point is noted at the bottom of the first page in the article).
Pal S., Vishwanath SN, Edjument-Bromage H, Tempst P, Sif S. 2004. Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. Mol. Cell. Biol. 24:9630-9645.
Pal S., Yun R, Datta A, Lacomis L, Edjument-Bromage H, Kumar J, Tempst. P, Sif S. 2003. mSin3A/HDAC2 and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad. Mol. Cell. Biol. 23:7475-7487.
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Ravi Gupta, Ph.D.
Postdoctoral Research Fellow
215-495-6837 rgupta@wistar.org
Ravi joined Center for Systems & Computational Biology, Davuluri Lab in September 2008. He received his PhD from Indian Institute of Technology Roorkee, India in November 2007 under supervision of Dr. Ankush Mittal and Dr. Kuldip Singh. His PhD work was on application of signal processing and pattern recognition techniques for sequence analysis. He work for a short period as a Member Research Staff of AU-KBC Research Center, Information Science Division at Chennai, India (http://www.au-kbc.org/). His current work includes analyzing and developing computational tools for small non-coding RNAs (especially siRNAs), RNA-editing and promoter data generated by ultra high-throughput sequencer (Solexa).
Website: http://raavigupta.googlepages.com/
Publications
S. Majumdar, M. Rajaram, A. Mulay, H. S. Reddy, K. P. Tamilarasan, G. K. Kolluru, S. Sinha, J. H.Siamwala, R. Gupta , R. Iliavarasan, S. Venkataraman, K. C. Sivakumar, S. Anishetty, P. G. Kumar, S. C. Chatterjee, "Thalidomine attenuates nitric oxide driven angiogenesis by interplaying with soluble guanylate cyclase", British Journal of Pharmacology, 2009. [Accepted]
S. Majumdar, R. Gupta , H. S. Reddy, S. Sinha and S. Chatterjee, "Cadmium attenuates bradykinin driven nitric oxide production by interplaying with the localization pattern of endothelial nitric oxide synthase", Biochemistry and Cell Biology, 2009. [Accepted]
R. Gupta , A. Mittal, K. Singh, V. Narang and S. Roy, "Time-series approach to Protein Classification Problem," IEEE Engineering in Medicine and Biology Magazine, pp. 1-5, 2009.[Accepted]
R. Gupta , A. Mittal and K. Singh, "A time series based feature extraction approach for prediction of protein structural class," EURASIP Journal on Bioinformatics and Systems Biology, Article ID 35451, pp. 1-7, 2008. [PMID: 18464911]
R. Gupta , A. Mittal and K. Singh, "A novel and efficient technique for identification and classification of GPCRs," IEEE Transaction on Information Technology in Biomedicine, pp. 1-8, 2007. [PMID: 18632334]
R. Gupta , D. Sarthi, A. Mittal and K. Singh, "A novel signal processing measure to identify exact and inexact tandem repeat patterns in DNA sequences," EURASIP Journal on Bioinformatics and Systems Biology, Article ID 43596, pp. 1-7, 2007. [PMID: 17713591]
S. Padmaja, J. Lakshmanan, R. Gupta and S. Banerjee, Genome-wide organization of S/MARs in the parasitic protozoa Giardia lamblia. (under communication)
S. Padmaja, J. Lakshmanan, R. Gupta and S. Banerjee, "Blueprint of S/MARs in the genome of protozoan parasite Giardia lamblia," in 7th Annual meeting of Society of Biological Chemists , Chennai, India, Dec. 18-20, 2008. [Awarded Best Poster]
R. Gupta, A. Mittal, K. Singh, P. Sharma and A. Sharma, "Identification of nuclear receptors and its family using wavelet variance features," In Proc. 10th International Conference on Information Technology (ICIT 2007), Rourkela, India, pp. 68-73, 17-20 December, 2007.
R. Gupta, A. Mittal, K. Singh, P. Bajpai and S. Prakash, "A time series analysis approach for identification of exons and introns," In Proc. 10th International Conference on Information Technology (ICIT 2007), Rourkela, India, pp. 91-93, 17-20 December, 2007.
R. Gupta, A. Mittal, K. Singh, V. Narang and S. Roy, "Wavelet variance features for identification and classification of GPCRs using SVM," In IAPR Workshop on Pattern Recognition in Bioinformatics (PRIB 2007), Singapore, pp. 1-12, October 1-2, 2007. [One of the ten papers selected for publication in IEEE Engineering in Medicine and Biology Magazine]
R. Gupta, A. Mittal and K. Singh, "Discrete wavelet transform features for classification of protein coding regions in DNA sequences using SVM," In Proc. International Conference on Bioinformatics (InCoB 2006), New Delhi, Poster no. P-046, December 18-20, 2006.
R. Gupta, A. Mittal and K. Singh, "Identifying inverted repeat structure in DNA sequences using correlation framework," In Proc. European Conference on Signal Processing (EUSIPCO 2006), Italy, pp. 1865.1-1865.5, September, 2006.
R. Gupta, D. Sarthi, A. Mittal and K. Singh, "Exactly periodic subspace decomposition based approach for identifying tandem repeats in DNA sequences," In Proc. European Conference on Signal Processing (EUSIPCO 2006), Italy, pp. 1857.1-1857.5, September, 2006.
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